Head & Neck Cancer

Head and neck cancer-related tumor hypoxia detected by positron emission tomography

Published in Cancer Weekly, July 18th, 2006

The risk of locoregional failure (LRF) in head and neck cancer patients receiving a nontirapazamine-containing chemoradiotherapy regimen could be related to tumor hypoxia.

Researchers in Australia conducted a study "to determine the association between tumor hypoxia, treatment regimen, and LRF in patients with stage III or IV squamous cell carcinoma of the head and neck randomly assigned to radiotherapy (70 Gy in 35 fractions over 7 weeks) plus either tirapazamine and cisplatin in weeks 1, 4, and 7 and tirapazamine alone in weeks 2 and 3 (TPZ/CIS) or cisplatin and infusional fluorouracil during weeks 6 and 7 (chemoboost)."

"Forty-five patients were...

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Source: Cancer Weekly (2006-07-18)

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