Acute Myeloid Leukemia
Acute myeloid leukemia prognosticated by size of FLT3 internal tandem duplication
Published in Cancer Weekly, July 18th, 2006
According to a study from the United States, "FLT3/ITDs in the juxtamembrane domain are found in approximately 25% of AML patients, ranging in size from 3 to hundreds of nucleotides. We examined whether the sizes of FLT3/ITDs were associated with clinical outcomes in 151 AML patients enrolled in Southwest Oncology Group studies: S9333 and S9500."
"FLT3/ITDs were identified in 32% of patients (median ITD size=39 nucleotides; range, 15-153 nucleotides). The CR rates were 35%, 67%, and 52% for patients with large (<40), small (<40), and...
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Source: Cancer Weekly (2006-07-18)
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