Cancer Therapy
Perifosine inhibits Akt and induces cytotoxicity in human multiple myeloma cells
Published in Cancer Weekly, July 18th, 2006
According to a study from the United States, "Perifosine is a synthetic novel alkylphospholipid, a new class of antitumor agents which targets cell membranes and inhibits Akt activation. Here we show that baseline phosphorylation of Akt in multiple myeloma (MM) cells is completely inhibited by perifosine [octadecyl-(1,1-d imethyl-piperidinio-4-yl)-phosphate] in a time- and dose-dependent fashion, without inhibiting phosphoinositide-dependent protein kinase 1 phosphorylation."
T. Hideshima and colleagues at...
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Source: Cancer Weekly (2006-07-18)
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