Lung Cancer

Lung cancer associated with loss of heterozygosity and chromosomal instability

Published in Cancer Weekly, July 25th, 2006

Lung cancer was associated with loss of heterozygosity (LOH) and chromosomal instability, but not mini- and microsatellite instability.

According to researchers in Japan, "To investigate what kind of genetic instability plays important roles in lung carcinogenesis, we analyzed micro- and minisatellite instability, LOH and chromosome instability in 55 cases of lung cancer, including, 10 squamous cell, 5 large cell, and 3 small cell carcinomas, and 37 adenocarcinomas. Analysis of minisatellite instability, the mechanism of which is different from microsatellite instability, has not been reported previously."

"Minisatellite instability was detected in...

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Source: Cancer Weekly (2006-07-25)

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