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Non-Hodgkin Lymphoma

Non-Hodgkin lymphoma risk linked to cytokine polymorphisms in the Tb1/Th2 pathway

Published in Cancer Weekly, July 25th, 2006

Non-Hodgkin lymphoma (NHL) risk may be linked to cytokine polymorphisms in the Tb1/Th2 pathway.

According to recent research published in the journal Blood, "Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for autoimmune disorders, infectious diseases, and cancer. We analyzed one or more single nucleotide polymorphisms (SNPs) in 20 candidate Th1/Th2 genes in a population-based case-control study of NHL (n=518 cases, 597 controls) among women in Connecticut."

"SNPs in critical genes, IL4, IL5, IL6, and...

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