Cancer Weekly

Cancer Registries - Period estimates of cancer patient survival deemed more up-to-date than complete estimates

Diagnostics - Modified nucleosides and creatinine in urine samples used in early cancer detection

Diet & Nutrition - Consumption advisories of farmed salmon based on cancer risk reported

Gastrointestinal Stromal Tumor - Gastrointestinal stromal tumor apoptosis induced by flavopiridol

Prostate Cancer - Prostate cancer risk in African American men linked to common nonsense mutation in EphB2

Adrenocortical Cancer - Adrenocortical carcinoma management depends on better understanding of molecular pathogenesis

Anal Cancer - Anal cancer responded to mitomycin-C, adriamycin, cisplatin and bleomycin-CCNU

Anemia - Colorectal cancer and anemia interact to increase angiogenesis and cancer proliferation markers

Angiosarcoma - Cutaneous-type angiosarcoma reported in mature ovarian teratoma

Antibiotics - Prophylaxis dermatologic surgery in wound infections may be overused

Apoptosis - Apoptosis is induced in colon cancer cells following protein dissociation

Apoptosis - ARF-BP1 identified as potential therapeutic target against cancer

Apoptosis - Enhanced apoptosis is mediated by a p53 mutant

Apoptosis - Lung cancer apoptosis linked to upregulation of death receptors 4 and 5

Apoptosis - Molecular regulation of apoptosis effectors for cancer therapy discussed

Awards - H. Lee Moffitt Cancer Center moves up list of America's Best Hospitals for cancer

Awards - Seven finalists announced in BioWest 2006 Venture Showcase competition

Behavioral Medicine - Choosing for others differs from choosing for yourself in making treatment decisions

Biliary Malignancy - Patients with biliary malignancy underwent reconstruction of the right hepatic artery

Biomedical Engineering - Angiogenic growth factor lends a hand to adipogenic-differentiated preadipocytes

Bladder Cancer - A protein is key to bladder cancer spread, resulting in a potential drug target

Bladder Cancer - Bladder cancer prognosis is associated with HER3 and HER4 expression

Brain Cancer - Glioma uptake of radiotracers in rodent models varies with tracer type

Brain Cancer - Local control of brain metastases by stereotactic radiosurgery in relation to tumor margin dose discussed

Brain Tumor - Abnormal stimulation of a cellular trigger causes tumor-like growths in mice

Breast Cancer - Aggressive breast cancer cells are more invasive after Abl kinase activation

Breast Cancer - Avastin filed in Europe for first-line treatment of women with advanced breast cancer

Breast Cancer - Breast cancer cell growth is staunched by platelet-activating factor receptor antagonist

Breast Cancer - Breast cancer incidence in U.S. radiologic technologists analyzed

Breast Cancer - Breast cancer patient cosmesis improved with endoscopic breast-conserving surgery

Breast Cancer - Breast cancer risk in women with single, multiple, and atypical papilloma analyzed

Breast Cancer - Breast cancer risk reduced by estrogen receptor gene polymorphism in Spanish patients

Breast Cancer - Breast cancer therapy with radiation to carotid arteries does not increase risk of stroke

Breast Cancer - Breast cancer treated by 24-h continuous intravenous infusion of Yondelis

Breast Cancer - Down-regulation of polo-like kinase elevates drug sensitivity of breast cancer cells

Breast Cancer - Elevated osteopontin levels may predict poor survival in women with metastatic breast cancer

Breast Cancer - Estrogen receptor-positive breast cancers respond to therapy combining docetaxel and gefitinib

Breast Cancer - Four intraoperative breast cancer irradiation techniques compared

Breast Cancer - Inframammary crease breast carcinoma diagnostic and treatment challenges reviewed

Breast Cancer - Method developed to screen body fluids is highly accurate tool for spotting breast cancer cells

Breast Cancer - Practices of breast cancer radiotherapeutic management differ within Europe

Breast Cancer - Psychometric properties of revised Piper Fatigue Scale in Dutch cancer patients deemed satisfactory

Breast Cancer - Rho GTPase regulator promotes breast cancer cell invasiveness

Breast Cancer - Targeting strategies for women on dialysis who could benefit from mammography are described

Breast Cancer - Women breast cancer survivors have increased risk of developing second primary cancers

Breast Cancer - Women with lobular cancer may be good candidates for breast-conserving therapy

Breast Cancer Vaccine - CIITA-induced MHC class II expression leads to breast tumor rejection

Business & Finance - Hologic inks consent agreement with U.S. Federal Trade Commission regarding Mammotest

Business & Finance - Paradigm Therapeutics raises $7 million in fourth funding round

Business Update - Cell Therapeutics issues statement on study in women with lung cancer

Business Update - Viropro emphasizes commitment to increase its visibility

Cancer Gene Therapy - Antitumor responses generated by genetic modification of primary human T cells

Cancer Gene Therapy - Knockdown by small interfering RNA inhibits melanoma cell growth

Cancer Gene Therapy - Ovarian cancer gene therapy achieved with interferon-alpha-producing fibroblasts

Cancer Gene Therapy - Recombinant baculovirus used for malignant glioma therapy

Cancer Gene Therapy - Ribonucleic acid interference targeting suppresses anaplastic thyroid carcinoma

Cancer Registries - Cancer incidence in patients with systemic sclerosis was higher than in the general population

Cancer Research - Histone deacetylase inhibitor MS-275 pharmacokinetic profile evaluated in cancer patients

Cancer Research - No complete remissions observed in study of alemtuzumab for leukemia patients

Cancer Risk Factors - Cancer risks linked to LKB1 germline mutation carriers

Cancer Risk Factors - Hormone-related cancer risks may not be associated with phytoestrogen intake in women

Cancer Risk Factors - Ovarian neoplasia is higher in women with BRCA1/2 mutations undergoing salpingo-oophorectomy

Cancer Therapy - Advanced cancer patients did not experience survival benefit after low-molecular-weight heparin

Cancer Therapy - Exercise decreases pain and helps breast cancer survivors feel healthier, get back to living

Cancer Therapy - Locus Pharmaceuticals' new anticancer drug clears review period in U.S.

Cancer Therapy - Micro-RNA is involved in cholangiocarcinoma chemotherapy response

Cancer Therapy - Mutated mammary gland gene causes form of pediatric leukemia

Cancer Therapy - Reduced iodine efflux increases the intracellular retention time in thyroid cancer cells

Cancer Therapy - Refractory solid tumors did not respond to Anvirzel administered at phase I dosage level

Cancer Therapy - RITA launches LC Bead embolization product in U.S.

Cancer Therapy - Scripps researchers unveil strategy to create actively programmed anticancer molecules

Cancer Therapy - Stress kinase mediates cytotoxic effects of thalidomide analogue in cancer cells

Cancer Therapy - Tetraspanin participates in integrin-dependent tumor cell functions

Cancer Therapy - Thermal ablation with radiation therapy extends life expectancy of lung cancer patients

Cancer Therapy - U.K. teaching hospital tests complementary therapy protocols for cancer patients

Cancer Vaccine -  Eimeria protein elicits resistance to phlebovirus in mice but not hamsters

Cancer Vaccine - Adenovirus-based therapy needs modification to treat hypoxic components of tumors

Cancer Vaccine - Anticancer glycolipid monoclonal antibody induces tumor cell apoptosis

Cancer Vaccine - Dendritic cell vaccine induces T cell response against tongue squamous carcinoma

Cancer Vaccine - IL-13 receptor-alpha2 peptide analogues induce antiglioma CTL responses

Cancer Vaccine - Recepteur d'origine nantais (RON) tyrosine kinase is molecular target for epithelial cancers

Carcinogenesis - Impact of atmospheric polycyclic aromatic hydrocarbons in Asia reviewed

Carcinogenesis - Proximity to crops used to estimate residential exposure to agricultural herbicides in Iowa

Cell Biology - Interleukin receptor identified and functionally characterized

Cell Biology - Protection against hyperoxia is uncoupled from the ability to suppress growth

Cervical Cancer - Cervical cancer progression linked to inactivation of Rb by E7 in AKT activity upregulation

Cervical Cancer - Cervix cancer patients treated by pelvic radiotherapy did not experience degraded renal function

Cervical Cancer - Radical trachelectomy is associated with fewer short-term but more long-term morbidities

Cervical Cancer - Results for human papillomavirus testing show only modest variation during menstrual cycle

Cervical Cancer Vaccine - Human papillomavirus vaccines are the focus of review

Chemotherapy - Integrated BioPharma sub launches phase I trial of PhytoSel to reduce chemo's side effects

Chemotherapy - Norwood Immunology completes Melbourne bone marrow transplant clinical trial

Cholangiocarcinoma - Cholangiocarcinoma susceptibility linked to Clonorchis sinensis infection

Chondrosarcoma - Dedifferentiated central chondrosarcoma management discussed

Chordoma - Differential diagnosis between chordoid and chondroid tumors discussed

Chronic Myelogenous Leukemia - BCR-ABL is not an immunodominant antigen in chronic myelogenous leukemia

Chronic Myeloid Leukemia - Dasatinib targets earlier progenitors than imatinib in primary chronic myeloid leukemia

Clinical Trials - Curis and Genentech halt basal cell carcinoma Phase I clinical trial

Collaborations - MediGene, German Cancer Research Center initiate agreement to develop ovarian cancer antibody

Colon Cancer - DP1 plays tumor suppressor role in colon carcinogenesis

Colon Cancer Vaccine - Tumor antigen 5T4 vaccine induces immune responses that correlate with colorectal cancer control

Colorectal Cancer - Colorectal cancer metastatic recurrence linked to loss of heterozygosity on chromosomes 4 and 14q

Colorectal Cancer - Colorectal cancer methylator phenotype linked to JC virus T-antigen expression

Colorectal Cancer - Colorectal cancer patients suffer from psychological problems long after treatment

Colorectal Cancer - Colorectal cancer proliferation inhibited by Gli1 via Wnt signaling activation

Colorectal Cancer - Colorectal cancer proliferation, invasion, and metastasis are advanced by trypsin

Colorectal Cancer - Colorectal cancer risk factors in patients with sclerosing cholangitis discussed

Colorectal Cancer - Colorectal cancer survival after curative resection predicted by POSSUM

Colorectal Cancer - Colorectal cancers with altered beta-catenin produce excess securin

Colorectal Cancer - Epigenomics AG presents new clinical data on colorectal cancer screening markers

Colorectal Cancer - Fetal hemoglobin-blood cells developed within colorectal tumor tissues

Colorectal Cancer - Model to predict postoperative mortality in elderly colorectal cancer patients developed

Colorectal Cancer - Non-Lynch syndrome patients should also undergo colonoscopic surveillance, but at longer intervals

Cytomegalovirus & Lymphoma - Cytomegalovirus infection triggers lymphoma cell apoptosis in the liver

Diabetes Epidemiology - Diabetes can increase the risk of developing hepatocellular carcinoma

Diabetes Epidemiology - SorCS1 binds platelet-derived growth factor and may play role in islet vasculature in diabetes

Diagnostics - Cleaved endoplasmic reticulum proteins can be detected in sera in hepatocellular carcinoma

Diagnostics - Elevated Golgi pH linked to T-antigen expression in cancer cells

Diagnostics - F-18-FDOPA PET compared with F-18-FDG for diagnosing low-grade tumors

Diagnostics - Glioma tumor invasion quantified by novel technique using serial microscopy sections

Diet & Nutrition - Dietary agents applied as histone deacetylase inhibitors

Diet & Nutrition - Methods used to summarize data on diet-cancer associations described

Disease Associations - Macrophage activating syndrome is associated with lobular hepatitis

Drug Delivery - Genetically engineered bacterium aids in prodrug therapy of mammary tumors

Drug Development - Efficient synthesis of achiral seco-cyclopropylbenz[ 2,3-e] indoline analogues developed

Drug Development - Imino-tetrahydro-benzothiazole derivatives proposed as p53 inhibitors

Drug Development - Interferon-alpha therapy contributes to weight loss by increasing adipocyte apoptosis

Drug Development - Novel synthesis of nicotinamide derivatives with cytotoxic properties described

Drug Development - Peptide p160 with affinity for neuroblastoma cells was developed

Drug Development - PhytoMedical partners with Ricerca to develop compound for cachexia

Drug Transport - Modulation of paclitaxel transport by flavonoid derivatives in human breast cancer cells discussed

Endometrial Cancer - Endometrial cancer arose in both horns of didelphys uterus in a woman with Down syndrome

Endometrial Cancer - Endometrial cancer follow-up schedule after primary therapy discussed

Epidemiology - Prediction model of hepatocarcinogenesis validated

Epidemiology - Racial influences can explain differences in blood pressure among obese

Esophageal Cancer - Esophageal cancer patients with metal stents developed complications more frequently before chemoradiotherapy

Esophageal Cancer - Esophageal cancer sensitivity to peplomycin predicted by calpain/calpastatin expression levels

Finance - Bionovo receives $1 million grant to study nuclear transport regulation in cancer cells

Finance - EvoGenix offered $1.6 million grant for cancer drug program

Finance - Synta completes $40 million financing, funds to support multiple clinical programs

Finance - US Oncology announces closing of $100 million incremental term loan facility

Fitness & Wellness - Cancer patient qualify of life after therapy could be affected by exercise

Gastric Cancer - Gastric cancer apoptosis linked to expression of programmed cell death 5 gene

Gastric Cancer - Gastric cancer growth induced by COX-2 and mediated by MMP-2

Gastric Cancer - Gastric cancer risk linked to cyclooxygenase-2 polymorphisms in a Chinese population

Gastrinoma - Gastrinoma staging and treatment outlined

Gastrointestinal Stromal Tumor - Gastrointestinal stromal tumor prognosticated by mitotic activity

Genetics & Genomics - Halozyme announces lung cancer survival rates increase in mice with hyaluronidase enzyme candidate

Glioma - Glioma proliferation linked to enhanced fibroblast growth factor 2 signaling

Glottic Cancer - Carbon dioxide laser microsurgery effectively treats early glottic carcinoma

Glottic Cancer - Supraglottic cancer treated by routine bilateral neck dissection

Gynecological Cancer - Creatinine clearance is decreased after intensity-modulated radiotherapy

HIV/AIDS-Associated Hodgkin Disease - HAART improves survival in HIV-associated Hodgkin disease

Head & Neck Cancer - Head and neck SCC residual metastasis after chemoradiotherapy is not predicted by PET

Head & Neck Cancer - Head and neck squamous cell carcinoma care will improve with advances in proteomics and genomics

Healthcare Costs - Lung cancer chemotherapy regimens assessed in cost-minimization analysis

Hepatocellular Carcinoma - Association of hepatocellular carcinoma in hepatitis B virus carriers clarified

Hepatocellular Carcinoma - Hepatic iron overload induces hepatocellular carcinoma

Hepatocellular Carcinoma - Hepatocellular carcinoma patient survival prolonged with pulmonary resection of metastases

Hepatology - Angiotensinogen gene expression stimulated in kidney proximal tubular cells

Human Papillomavirus Diagnosis - Method to resolve borderline results of HPV DNA test has been developed

Hypopharyngeal Cancer - Hypopharyngeal cancer managed with intensity-modulated radiation therapy

Kaposi Sarcoma - Human herpesvirus 8 infection interferes with the endothelin system

Kaposi Sarcoma - Kaposi sarcoma-associated herpesvirus RTA induces transcriptional repressor

Kaposi Sarcoma - Peripheral blood dendritic cells and their precursors altered in classic Kaposi sarcoma

Kidney Cancer Vaccine - Peptide-pulsed dendritic cells elicit clinical responses in metastatic renal cancer

Leukemia - Childhood leukemia risk linked to birth weight and maternal weight

Leukemia - FHIT gene therapy using chimeric adenovirus shows promise for leukemia

Leukemia - Philadelphia chromosome-positive leukemia treated with dasatinib

Licensing Agreements - Tigris Pharmaceuticals enters license agreements for rights to targeted cancer compounds

Liposarcoma - Liposarcoma growth inhibited by quercetin

Liver Cancer - A variety of liver cancer activities are blocked by sulfatase 1 enzyme

Liver Cancer - Aggressive liver cancers are defined by Met gene signatures

Liver Cancer - Human telomerase reverse transcriptase elicits T cell responses in hepatocellular carcinoma

Liver Cancer - Murine liver cancer models uncover the effects of arsenic trioxide on tumor growth and angiogenesis

Lung Cancer - Cizzle continues development of protein focused diagnostic test and treatment for lung cancer

Lung Cancer - Combined modality therapy selection for stage III non-small cell lung cancer is age-dependent

Lung Cancer - Elderly lung cancer patients responded to weekly docetaxel and gefitinib, but experienced toxicity

Lung Cancer - Lung adenocarcinoma Akt activity may be the result of telomerase activation

Lung Cancer - Lung cancer carcinogenesis linked to overexpression of serine threonine kinase 15

Lung Cancer - Lung cancer managed with gemcitabine-cisplatin chemotherapy before lung resection

Lung Cancer - Lung cancer patients carry key genetic mutations in pleural effusions

Lung Cancer - Lung cancer patients did not benefit from intensification of gemcitabine dose

Lung Cancer - Lung cancer treated by single-agent gefitinib as first-line therapy

Lung Cancer - Lung cancer treatment efficacy of toxicity-adjusted topotecan therapy evaluated

Lung Cancer - Lung cancer tumorigenesis linked to G-protein signaling family of proteins

Lung Cancer - Lung diseases and cancer are exacerbated by factors that trigger mitogen-activated protein kinase

Lung Cancer - Murine lung cancer highlights the antiangiogenic properties of metronomic Rubiae isolate

Lung Cancer - Non-small cell lung cancer could be diagnosed by peptide ligands

Lung Cancer - Shortened lung cancer survival linked to development of postoperative pulmonary complications

Lung Tumor - Lung tumor growth suppressed by arachidonic acid

Lymphoma - Lymphoma outcomes after combined modality therapy deemed better than single modality therapy

Market Analysis - Market intelligence company MedPanel releases final study in Profiles in Oncology series

Market Analysis - Research and Markets releases report on treatment options for chronic lymphocytic leukemia

Melanoma - Melanoma endothelin receptor blockade augments the efforts of cancer therapy

Melanoma - Melanoma invasiveness mediated by CD13/aminopeptidase N overexpression

Melanoma - Melanoma risk in congenital melanocytic nevi reviewed

Melanoma - Nail apparatus melanoma prognosis influenced by concomitant traumas

Melanoma - Physician defines the normal number of melanocytes present in sun-exposed skin

Mental Health - Cancer patients benefited from meaning-making cancer coping strategies

Mergers & Acquisitions - Hologic acquires R2 Technology

Mergers & Acquisitions - IT&E International signs agreement to merge with Averion

Mergers & Acquisitions - Predicant Biosciences acquires Pathwork Informatics; names merged into company Pathwork Diagnostics

Mesothelioma - Patients with mesothelioma experience immunosuppression

Multiple Myeloma Therapy - Thalidomide analogue-induced neutropenia in multiple myeloma is linked to increase in neutrophils bearing CD64

Myeloma - Revlimid in combination with dexamethasone approved by U.S. Food and Drug Administration

Natural Products - Effects of various tea components on neoplastic cell transformation and carcinogenesis reviewed

Natural Products - New anticancer bastadin alkaloids isolated from the sponge Dendrilla cactos

Non-Hodgkin Lymphoma - Antibody maintenance therapy for non-Hodgkin lymphoma approved in Europe

Non-Hodgkin Lymphoma - ZymoGenetics begins trial of interleukin 21 with monoclonal antibody in non-Hodgkin lymphoma

Occupational Exposure - Incidence of leukemia, lymphoma, and multiple myeloma in Czech uranium miners studied

Oncology - Cancer cell migration, invasion and survival increase with phospholipase D upregulation

Oncology - Male patients with cancer have lower levels of biologically active testosterone