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Drug Development

Peptide p160 with affinity for neuroblastoma cells was developed

Published in Cancer Weekly, August 8th, 2006

The peptide p160 (VPWMEPAYQRFL) with affinity for neuroblastoma cells was developed.

According to a study from Germany, "Drug-targeting strategies can increase the efficacy and reduce the side effects and toxicity of conventional chemotherapy or may lead to new radiolabeled molecules useful for diagnosis and therapy. To identify and characterize new carrier molecules, we evaluated a peptide that had been identified by phage display technology. The peptide p160 was prepared by solid-phase peptide synthesis and radiolabeled with I-125 or I-131."

"The radiolabeled peptide and derivatives of it were used to study binding and internalization in vitro and...

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