Breast Cancer
Down-regulation of polo-like kinase elevates drug sensitivity of breast cancer cells
Published in Cancer Weekly, August 8th, 2006
"Human Plk1 is a key player in different stages of mitosis and modulates the spindle checkpoint at the metaphase-anaphase transition. Overexpression of Plk1 is observed in various human tumors and it is a negative prognostic factor in patients suffering from diverse cancers.
"We used phosphorothioate antisense oligonucleotides (ASO) targeted against Plk1, together with paclitaxel, carboplatin, and Herceptin, for the treatment of breast cancer cells to identify conditions for enhanced drug...
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Source: Cancer Weekly (2006-08-08)
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