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Prostate Cancer

Prostate cancer diagnosed by cytogenetic profiles alongside pathological features

Published in Cancer Weekly, August 15th, 2006

Cytogenetic profiles could be used as additional markers to pathological features for diagnosing prostate cancer.

"Fluorescence in situ hybridization analysis for evaluation of 7, 8, X chromosomes and EGFR, LPL, MYC, AR genes in 79 neoplastic foci from 56 patients with clinically localized prostate cancer was performed. We found aneusomy for chromosome 7, 8 and X in 74/77 (96.1%), 56/76 (73.7%), 26/70 (37.1%) of examined foci respectively," researchers in Italy reported.

"No specimen was amplified for EGFR and AR genes, only 2/71 (2.8%) specimens showed MYC gene amplified," explained M. Gallucci and colleagues, Regina Elena Cancer Institute. "LPL...

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