Breast Cancer

Breast cancer genes linked to drug resistance are detected by a new screening method

Published in Cancer Weekly, August 15th, 2006

Breast cancer genes linked to drug resistance are detected by a new screening method.

According to recent research from the Netherlands, "Antiestrogens, such as tamoxifen, are widely used for endocrine treatment of estrogen receptor-positive breast cancer. However, as breast cancer progresses, development of tamoxifen resistance is inevitable."

"The mechanisms underlying this resistance are not well understood. To identify genes involved in tamoxifen resistance, we have developed a rapid screening method. To alter the tamoxifen-sensitive phenotype of human ZR-75-1 breast cancer cells into a tamoxifen-resistant phenotype, the cells were infected with...

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Source: Cancer Weekly (2006-08-15)

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