Cancer Therapy

Cancer drug Gleevec can be toxic to the heart

Published in Cancer Weekly, August 15th, 2006

Gleevec, the wildly successful poster-child of a new generation of cancer drugs aimed at specific targets in the cancer cell, can be dangerous to the heart. Not only that, but other similarly based drugs - called tyrosine kinase inhibitors - could lead to heart problems as well, say researchers at the Center for Translational Medicine at Jefferson Medical College in Philadelphia.

A team of scientists led by Thomas Force, MD, James C. Wilson Professor of Medicine at Jefferson Medical College of Thomas Jefferson University, has shown in studies in both mice and in heart cells in culture that Gleevec can cause heart failure. The results of the study, prompted by 10...

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Source: Cancer Weekly (2006-08-15)

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