Hepatitis C Virus
Hepatitis C virus proteins increase expression of heme oxygenase in hepatoma
Published in Cancer Weekly, August 29th, 2006
"Hepatitis C infection induces hepatic oxidative stress. HO, the rate-controlling enzyme of heme catabolism, plays a key role as a protector against oxidative, and other stresses.
"Other recent work has implicated Bach1, a heme binding protein that represses gene expression, in the regulation of HO-1 gene expression. We investigated the effects of HCV polyprotein expression on expression of HO-1 and Bach1 genes in human hepatoma cells (Huh-7 cells)," wrote T....
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Source: Cancer Weekly (2006-08-29)
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