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Non-small Cell Lung Cancer

Exelixis initiates Phase II trial for XL647 in patients with metastatic non-small cell lung cancer

Published in Cancer Weekly, August 29th, 2006

Exelixis, Inc. (EXEL) announced the initiation of a Phase II trial of XL647, an orally bioavailable small molecule inhibitor of the HER2, EGF, VEGF and EphB4 receptor tyrosine kinases (RTKs).

Although these individual RTKs are targets for currently approved therapies, XL647 was designed to potently inhibit all three targets simultaneously. The trial will be conducted in patients with advanced (stage IIIB or IV) non-small cell lung cancer (NSCLC) who have not previously been treated with chemotherapy. In this proof-of-concept trial, participants must meet at least two of the following criteria: Asian, female, non-smoker or adenocarcinoma.

"We designed...

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