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Lung Cancer

Non-small cell lung cancer metastasis is marked by aminopeptidase N

Published in Cancer Weekly, September 5th, 2006

Non-small cell lung cancer (NSCLC) metastasis is marked by aminopeptidase N (APN/CD13).

"The aim of our study is to investigate the mechanism of metastasis, to detect novel metastasis-associated molecules, and to evaluate the molecules from the point of view of clinical application. A monoclonal antibody MH8-11, which we established, recognizes a glycoprotein that is identical to APN/CD13," scientists in Japan report.

T. Tokuhara and colleagues, Kitano Hospital, wrote, "APN/CD13 degrades the extracellular matrix, while it is also involved in cell motility and improves angiogenesis. We investigated the expression of APN/CD13 in 194 cases of NSCLC by...

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