Published in Cancer Weekly, September 5th, 2006
According to recent research published in the journal Bioorganic & Medicinal Chemistry, "Two new glucuronide paclitaxel prodrugs have been synthesized."
"Linked to the 2'-OH of the drug by a carbonate function, they include a self-immolative spacer bearing an arylnitro or arylamino group between the drug and the glucuronic acid residue. Both prodrugs were well detoxified and easily cleaved in the presence of P-D-glucuronidase with fast removal of the spacer, releasing paclitaxel," explained A. Elalaoui and colleagues, Institut Curie.
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