Cancer Weekly

Breast Cancer - Breast cancer outcome associated with status of p53 and MDM2 SNP309

Crohn Colitis - Crohn colitis patients requiring surgery linked to higher risk of dysplasia and adenocarcinoma

End-of-Life Issues - End-of-life cancer patients' spiritual needs measured by Spiritual Needs Inventory

Endometrial Cancer - Endometrioid endometrial carcinoma's loss of PTEN expression linked to cyclin D1 overexpression

Lung Cancer - Lung cancer patients could safely receive higher doses of radiation than traditionally administered

Acute Lymphoblastic Leukemia - Acute lymphoblastic leukemia remission is likely when lymphangiogenesis factor is absent

Acute Lymphoblastic Leukemia - Hana initiates Marqibo phase II trial in relapsed or refractory acute lymphoblastic leukemia

Acute Myeloid Leukemia - Acute myeloid leukemia is detected by angiogenesis biomarkers

Acute Myeloid Leukemia - Acute myeloid leukemia progression prognosticated by serum levels of sCD137

Adrenal Myelolipoma - Adrenal myelolipoma case study presented

Adrenocortical Cancer - Adrenocortical cancer clinical and biological features and prognostic factors studied

Adrenocortical Cancer - Adrenocortical carcinoma immunotherapy elicits angiogenic stability but not clinical improvement

Adverse Drug Reaction - Jaw osteonecrosis induced by use of bisphosphonates

Alveolar Cancer - Pulmonary lesions with pure ground-glass opacity surgical recommendations listed

Apoptosis - Apoptotic cells detected using a paramagnetic lipidic coating

Apoptosis - Breast cancer cell apoptosis and growth inhibition induced by truncated cadherin

Apoptosis - Fhit protein physiological and pathological aspects discussed

Apoptosis - Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway

Apoptosis - Relevance of APAF-1 pathway in apoptosis is cell-context-dependent

Apoptosis - Tumor necrosis factor-related apoptosis-inducing ligand sensitizes tumors

Arthropathy - Chemotherapy-related arthropathy favorable prognosis related to early treatment

Astrocytoma - Anaplastic astrocytoma time-to-tumor progression and survival predicted by residual tumor volumes

Awards - Frost & Sullivan lauds MEDRAD's excellent product innovation abilities in the MRI coils market

Bladder Cancer - Bladder cancer diagnosed by computed tomography urography

Bladder Cancer - Bladder carcinoma progression predicted by p53, p27(Kip1), and alpha-catenin

Bladder Cancer - Intravesical docetaxel tested for refractory superficial bladder cancer

Bladder Cancer - Targeted bladder cancer screening using tumor markers may be cost effective

Bowel Cancer - Bowel cancer survivors need supportive care after surgery to manage chronic symptoms

Brain Cancer - Gliomas in tumor models respond to nanoparticle-based drug delivery

Brain Metastases - Brain metastases responded to vinorelbine combined with protracted course of temozolomide

Breast Cancer - Breast cancer and bone metastases management by bisphosphonates may prove to be cost effective

Breast Cancer - Breast cancer cell cycle arrest is induced by Physalis angulata

Breast Cancer - Breast cancer growth inhibited by superoxide dismutase overexpression

Breast Cancer - Breast cancer models show cyclooxygenase-2 bolsters tumor angiogenesis

Breast Cancer - Breast cancer patients did not benefit from hyperfractionated postmastectomy radiotherapy

Breast Cancer - Breast cancer patients with lymphoscintigraphic evidence of lymphatic drainage need long-term follow-up

Breast Cancer - Breast cancer progression inhibited by Delta(9)-tetrahydrocannabinol

Breast Cancer - Breast cancer response to prooxidant drugs predicted by p53 status

Breast Cancer - Breast cancer treated by radiotherapy after high-dose dense chemotherapy

Breast Cancer - Breast cancer treatment between-surgeon variation reduced by broader dissemination of guidelines

Breast Cancer - Breast cancer tumor grade linked to breast cancer specific gene-1 expression

Breast Cancer - Breast cancers remain static and angiogenesis declines in models given soy extract

Breast Cancer - Epithelial cells in nipple aspirate fluid may signify increased breast cancer risk

Breast Cancer - Ethnic trends in breast cancer risk may signify need for targeted prevention strategies

Breast Cancer - Expert challenges corporatization of breast cancer research

Breast Cancer - Gene regulation characteristic of tamoxifen may be an advantage over aromatase inhibitors

Breast Cancer - Levels of a protein in breast cancer tumors indicates potential response to chemotherapy

Breast Cancer - New criteria can improve PET scan reliability in detecting breast cancer metastasis

Breast Cancer - Nucleotide excision repair polymorphisms may modify association between breast cancer/smoking

Breast Cancer - Occult contralateral cancers' rarity may not warrant routine sentinel node mapping

Breast Cancer - Older age should not be deterrent for offering breast reconstruction option for cancer patients

Breast Cancer - Pharmexa discontinues Phase II trial of breast cancer vaccine

Breast Cancer - Regular screening improves survival for cancer patients with family history of breast cancer

Breast Cancer - Study finds cardiac toxicity high when Herceptin used but reversal possible with treatment

Breast Cancer - Study provides clearer picture of breast-cancer gene mutations in American women

Breast Cancer - [¹⁸F]fluorodeoxyglucose positron emission tomography improves stratification for cancer survival

Business & Finance - Chemokine Therapeutics announces second quarter financial and operating results

Business & Finance - ChondroGene reports second quarter 2006 financial results

Business & Finance - Ciphergen reports second quarter financial results and substantial development progress

Business & Finance - Cyclacel Pharmaceuticals reports second quarter net loss of $6.9 million

Business & Finance - IntraOp Medical announces Q3 revenues of $85,419

Business & Finance - Microbix' Q3 2006 reported net loss of $233,477 reflects investment in large-market products

Business & Finance - Micromet reports in its unaudited Q2 2006 results recognized revenues of $5 million

Business & Finance - Pro-Pharmaceuticals reports second-quarter 2006 results

Business Update - Antisoma reports on partnering and development efforts related to AS1404

Business Update - Digi-Solve introduces All-Inclusive Digital Mammography Fee-Per Procedure Program

Business Update - Valeant Pharmaceuticals announces U.S. availability of synthetic cannabinoid for nausea

Cancer Coping - Cancer patients' spiritual needs and preferences assessed by SPIR interview

Cancer Epidemiology - Epidemic increase in non-Hodgkin's lymphoma in Scandinavian countries has subsided

Cancer Gene Therapy - Alveolar rhabdomyosarcoma gene expression signature identified

Cancer Gene Therapy - An immunological synapse allows tumor targeting by vector particles

Cancer Gene Therapy - Bladder cancer adenovirus-mediated gene therapy modeled

Cancer Gene Therapy - Breast cancer-associated gene absence increases expression of axis members

Cancer Gene Therapy - Malignant breast cancer cell cycle arrest induced by downregulation

Cancer Pain - Cancer pain self-management by attentional pain control strategies evaluated

Cancer Therapy -  Ganoderma lucidum extract induced apoptosis in the cells of hematologic malignancies

Cancer Therapy - Antitumor activity of JS-K shown potent in both in vivo activities and rat liver model

Cancer Therapy - Cancer immunotherapy by interleukin-21 evaluated in a mathematical model

Cancer Therapy - Cancer models treated with radiotherapy and imatinib exhibit reduced tumor growth

Cancer Therapy - Cancer therapies need to be developed that maintain quality of life and extend life

Cancer Therapy - Childhood cancer survivors are at risk for suicidal thoughts and attempts

Cancer Therapy - Circulating dendritic cells studied in resected high-risk cutaneous melanoma

Cancer Therapy - Consensus recommendations for imaging and oncologic drug development are needed

Cancer Therapy - Human p53 transcription regulation maintains cell cycle checkpoints

Cancer Therapy - Mammary tumor potential targets identified

Cancer Therapy - Melanoma cell immune evasion requires a signaling pathway

Cancer Therapy - Pegylation improves the stability of antiangiogenic protein endostatin

Cancer Therapy - Raven presents encouraging results from study of RAV12 antibody for adenocarcinomas

Cancer Therapy - Signature of chromosomal instability predicts cancer outcomes

Cancer Therapy - Specialists encourage women to learn their family health history

Cancer Therapy - Sphingosine kinase inhibitors display antitumor activity

Cancer Therapy - Study identifies the molecular process underlying leukemia

Cancer Therapy - Transcription factor overexpression sensitizes cells to antimitotic agents

Cancer Vaccine - Targeting tumor-associated fibroblasts increases intratumoral drug uptake

Carcinogenesis - Sustained activation of ERK pathway commits cells to autophagic vacuolation

Carcinoid Tumors - Carcinoid tumors treated by bronchoplastic lobectomy

Central Nervous System Metastases - Central nervous system metastases responded to systemic high-dose intravenous methotrexate

Cervical Cancer - Cervical cancer screening using semiautomated DNA ploidy is sensitive and specific

Cervical Cancer - siRNA proposed as a novel radiation/chemotherapy-sensitizing agent

Chemotherapy - Combined chemotherapy-virotherapy inhibits multidrug-resistant phenotype

Cholangiocarcinoma - Cholangiocarcinoma risk in the Republic of Korea increased with Clonorchis sinensis infection

Cholangiocarcinoma - Cholangiocarcinoma tumor invasion linked to FAK signaling in TNF-alpha-dependent MMP-9 production

Chondroblastoma - Chondroblastoma tumor progression is probably unrelated to p53

Chronic Lymphocytic Leukemia - A new strain of mice offers the first real animal model for an incurable form of chronic leukemia

Clinical Trials - Application of clinical trial results to individual cancer patient management discussed

Clinical Trials - Northwest Biotherapeutics signs Synteract to manage DCVax-Brain Cancer trial

Collaborations - Medinet and MaxCyte sign agreement to collaborate in developing cancer immuno-cell therapy

Colon Cancer - Colon carcinoma apoptosis induced by tricyclic antidepressants

Colon Cancer - Colon carcinoma cell molecular target identified

Colon Cancer - Colorectal cancer diagnosis by FDG-PET/CT determines necessity of laparotomy

Colorectal Cancer - Colorectal cancer cell telomere attrition produced by telomerase inhibition

Colorectal Cancer - Colorectal cancer multistep pathogenesis involves accumulation of CpG island methylation of genes

Colorectal Cancer - Colorectal carcinoma grade linked to expression of TfR1

Complementary & Alternative Medicine - Acupuncture and acupressure helped reduce chemotherapy-induced nausea

Developmental Biology - Sarcoma cell growth isoform production induces vasculogenesis

Developmental Biology - Tumor and normal cells cultured in microcapsules studied

Diabetes Research - Medros to conduct screenings for drugs to treat diabetes and cancer

Diagnostics - Advanced approach for intraoperative MRI guidance may benefit neurosurgical interventions

Diagnostics - Endoscopic ultrasound holds potential for many applications

Drug Delivery - PEOz-b-PLLA diblock polymeric micelles proposed as drug carriers for cancer therapy

Drug Development - Cancer models given ZD6474 reflect key pharmacokinetic activity

Drug Development - CD-ring of the anticancer agent streptonigrin synthesis described

Drug Development - Isoquinoline-containing polycyclic quinones synthesized and studied for cytotoxic properties

Dysphagia - Dysphagia and bleeding interventions published in 2005 were reviewed

Embryonic Stem Cell Research - Melanocytes can be induced from embryonic stem cells

Endometrial Cancer - Endometrial cancer risk is associated with age at menopause and years of menstruation

Endometrial Cancer - Endometrial carcinoma with microsatellite instability targets the Birt-Hogg-Dube gene

Environmental Health - Potential benefits of sun exposure not substituted by oral vitamin D supplementation

Environmental Health - Radiation doses received by cleanup workers of Chornobyl accident estimated

Environmental Health - Thyroid cancer incidence was heightened in Ukraine after Chornobyl accident

Esophageal Cancer - Esophageal cancer angiogenesis may be driven by cyclooxygenase-2 expression

Finance - IDM Pharma reports second quarter revenues of $3.0 million

Focal Liver Lesions - Focal liver lesions characterized by contrast-enhanced sonography with a low mechanical index mode

Fungal Infection & Cancer - Aggressive anticancer therapy and neutropenia linked with fungal infections

Fungal Prophylaxis - Fungal infection incidence similar in transplant patients given itraconazole or fluconazole

Gastric Cancer - Early gastric cancers with lymph node micrometastasis are revealed by genetic markers

Gastric Cancer - Risk of developing gastric cancer associated with Helicobacter pylori determined

Gastroenterology - Gastrin's role in cancer reviewed

Gene Research - Scientists uncover a critical step in DNA mutation that could lead to new cancer therapies

Gene Research - UVRAG positively regulates Beclin1-PI(3) KC3 complex, an inducer of autophagy

Germ Cell Cancer - Germ cell tumor of the spine treated by resection and chemotherapy

Germ Cell Cancer - Testicular germ cell tumors regressed spontaneously

Glioma - Glioma apoptosis linked to BCL-x(L)

Glioma - Glioma favorable prognosis linked to mutant TP53 with alternative lengthening of telomeres

Glioma - Glioma responds to cystemustine

Graft-versus-Host Disease - Progenitor cells trapped in bone marrow filters can reduce graft-versus-host disease

Gynecology - Carcinomas of the female genital tract developed after pelvic irradiation

HIV/AIDS Oral Hairy Leukoplakia - Risk factors for oral hairy leukoplakia in HIV/AIDS patients determined

Head & Neck Cancer - Head and neck cancer radiotherapy treatment planning performed with FDG-PET

Head & Neck Cancer - Head and neck cancer receives alternative regimen in docetaxel chemoradiotherapy

Head & Neck Cancer - Squamous cell carcinoma of the parotid gland detected by neck dissection with parotidectomy

Healthcare Access - U.K. Biobank gets unanimous backing from international experts after piloting phase

Hemangioma & Anemia - Splenic cord capillary hemangioma patient resolved of anemia with splenectomy

Hemihyperplasia - Isolated hemihyperplasia patients with uniparental disomy at 11p15 have higher tumor risk

Hepatitis B Virus - Kinetics and risk of hepatitis B infection monitored in cytotoxic chemotherapy

Hepatitis C Virus - Chronic hepatitis C viral kinetics monitored during treatment

Hepatocellular Cancer - Hepatitis-related liver cancer is associated with suppressor of cytokine signaling-3 gene deletion

Hepatocellular Cancer - Hepatocellular carcinoma autoantibodies analyzed proteomically

Hepatocellular Cancer - Liver cancer prognosis is relayed by angiogenesis factors

Hodgkin Lymphoma - Hodgkin lymphoma patients with bulky lymph nodes estimated by power Doppler ultrasound scanning

Human Papillomavirus Vaccine - Mothers have positive attitudes toward human papillomavirus vaccination

Hyperthyroidism & Thyroid Cancer - Hyperthyroidism's link to thyroid cancer needs careful examination

Imaging - Breast masses could be detected by radiologists using 2D or 3D ultrasonographic data

Immunology - Mechanisms and consequences of UV-induced immunosuppression are reviewed

Inflammatory Bowel Disease - Mechanical bowel obstruction cases of intra-abdominal tumor compared to non-tumoral origin

Kaposi Sarcoma-Associated Herpesvirus - Kaposi sarcoma-associated herpesvirus targets multiple leukocyte lineages

Leukemia - Acute lymphoblastic leukemia poor prognosis predicted by Aven overexpression

Leukemia - Acute myelogenous leukemia cytogenetic abnormalities differed between geographic regions in Spain

Leukemia - Childhood acute myeloid leukemia survival influenced by ethnicity

Leukemia - Chronic lymphocytic leukemia treatment could be treated with weekly clofarabine

Leukemia - Leukemia patients identified with seemingly normal circulating dendritic cell compartment

Leukemia - Leukemia response to topoisomerase II poisons reduced when treated with digitoxin concurrently

Liposarcoma - Liposarcoma cell releases superoxide dismutase suppresses tumors

Liver Cancer - Liver cancer is enhanced by aflatoxin-B exposure

Lung Cancer - Image-guided radiotherapy for lung cancer targets tumors while adapting for movement

Lung Cancer - Large cell neuroendocrine cancers of lung and small cell lung cancers have unique LOH patterns

Lung Cancer - Lung cancer apoptosis induced by p53 was promoted by upregulation of BNIP3

Lung Cancer - Lung cancer patients pretreated with taxane-based regimen managed with vinorelbine and cisplatin

Lung Cancer - Lung cancer quality of life better maintained by docetaxel/carboplatin regimen

Lung Cancer - Lung cancer treated by carboplatin and fixed dose rate gemcitabine infusion

Lung Cancer - Lung cancers harbor differentiation markers useful for identifying adenocarcinoma

Lung Cancer - Lung cancers with a key mutation can be diagnosed with a new rapid assay

Lung Cancer - Malignant pulmonary nodules detected by software volumetric evaluation of doubling times

Lung Cancer - Non-small cell lung cancer pathogenesis possibly linked to deregulation of cytoglobin

Lung Cancer - Non-small cell lung cancer progression parallels the presence of circulating progenitor cells

Lung Cancer - Poniard completes enrollment in picoplatin Phase II small cell lung cancer clinical trial

Lung Cancer - Squamous lung carcinoma outcome in elderly compared to younger patients

Lymphoma - ALK+ anaplastic large cell lymphoma finds new potential treatment option in mTOR inhibition

Lymphoma - Complement-induced cell death by rituximab depends on CD20 expression

Lymphoma - Primary cutaneous marginal zone B-cell lymphoma linked to aberrant nuclear BCL10 expression

Lymphoma - Rituximab may be a favorable adjuvant to intensive sequential chemotherapy

Lymphoproliferative Disorder - Fulminant EBV-associated T cell lymphoproliferative disorder occurred after SC transplantation

MALT Lymphoma - Ocular adnexal MALT lymphoma's link to Chlamydia psittaci varies in different geographical regions

Medulloblastoma - Medulloblastoma survival predicted by degree of anaplasia

Melanoma - Melanoma apoptosis induced by porphirin derivatives

Melanoma - Melanoma development promoted by epigenetic PTEN silencing

Melanoma - Melanoma radiotherapy strategies are being developed

Melanoma - Melanoma worse prognosis linked to estrogen receptor-alpha methylation

Melanoma - Provectus melanoma investigator validates therapeutic use of PV-10

Melanoma Vaccine - Dendritic cells of melanoma patients present protein to T cells after Fc gamma RII-mediated uptake

Melanoma Vaccine - Semliki Forest virus in melanoma xenografts was examined for oncolytic capacity

Meningioma - Tuberculum sellae meningioma resection functional outcomes are assessed

Mergers & Acquisitions - TriPath announces receipt of Becton, Dickinson proposal to acquire outstanding TriPath shares

Myeloma - Myeloma cells were sensitized by trichostatin A

Natural Products - Dihydronitidine exhibited tumor specific cytotoxicity

Natural Products - Ehrlich tumors responded to antineoplastic effects of butanolic residue of Pfaffia paniculata

Natural Products - Prostate cancer apoptosis induced by tocotrienol-rich fraction of palm oil

Nephrology - von Hippel-Lindau gene function is required for cilium formation in kidney cells

Non-Hodgkin Lymphoma Treatment - Intravenous busulfan improves outcomes in non-Hodgkin lymphoma

Nonmelanoma Skin Cancer - Nonmelanoma skin cancers weakly affected by nonsteroidal antiinflammatory drugs