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Hepatocellular Cancer

Hepatocellular carcinoma autoantibodies analyzed proteomically

Published in Cancer Weekly, September 12th, 2006

In a recent study, researchers in Japan reported on a proteomic analysis of autoantibodies in patients with hepatocellular carcinoma (HCC).

"To detect autoantibodies that could be diagnostic markers for HCC, we analyzed serum autoantibodies comprehensively that showed immunoreactivity to proteins in tumor tissue obtained from patients with HCC. Fifteen paired samples of HCC tissue and corresponding nontumorous liver tissue as well as five normal liver tissue samples were used in the study," wrote M. Takashima and colleagues, Yamaguchi University.

They explained, "A combination of proteomics and SEREX (serologic analysis of recombinant cDNA expression...

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