Melanoma
Melanoma apoptosis induced by porphirin derivatives
Published in Cancer Weekly, September 12th, 2006
According to recent research published in the journal Cancer Letters, "The cytotoxic effect of several diorganotin(IV) and triorganotin(IV)-meso-tetra(4-sulfonatophenyl)porphine derivatives was tested and only the (Bu2Sn)(2)TPPS and the (Bu3Sn)(4)TPPS showed cytotoxicity on A375 human melanoma cells. To examine the pathway of (Bu2Sn)(2)TPPS or (Bu3Sn)(4)TPPS induced A375 cell death, DNA fragmentation analysis, Annexin V binding and PI uptake as well as caspases activation analysis by Western blot were carried out."
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Source: Cancer Weekly (2006-09-12)
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