Stem Cell Research
Suz12 binds to silenced regions of genome in cell-type-specific manner
Published in Cancer Weekly, September 12th, 2006
"Suzl2 is a component of the Polycomb group complexes 2, 3, and 4 (PRC 2/3/4). These complexes are critical for proper embryonic development, but very few target genes have been identified in either mouse or human cells.
"Using a variety of ChIP-chip approaches, we have identified a large set of Suz12 target genes in five different human and mouse cell lines," wrote investigators in the United States.
"Interestingly," wrote S.L. Squazzo and colleagues at the University of California, Davis, "we found that Suz12 target promoters are cell type specific,...
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Source: Cancer Weekly (2006-09-12)
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