Acute Myeloid Leukemia
Fms-like tyrosine kinase 3/ITD is a relevant marker for acute myeloid leukemia prognosis
Published in Cancer Weekly, September 19th, 2006
According to recent research from the Netherlands, "In acute myeloid leukemia (AML), activating mutations in the fms-like tyrosine kinase 3 (FLT3) gene predict poor prognosis. We determined FLT3 internal tandem duplications (FLT3/ITD) and D835 point mutations in paired initial and relapse samples from 80 pediatric and adult AML patients."
"One D835 point mutation was found in an initial pediatric AML sample. Fms-like tyrosine kinase 3/ITDs were present in 21 initial and 22 relapse samples (26.3 and 27.5%, respectively).
"Interestingly,...
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Source: Cancer Weekly (2006-09-19)
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