Hepatocellular Carcinoma
Pediatric hepatocellular carcinoma risk linked to bile salt export pump deficiency
Published in Cancer Weekly, October 10th, 2006
"HCC is rare in young children. We attempted to see if immunohistochemical and mutational-analysis studies could demonstrate that deficiency of the canalicular bile acid transporter BSEP and mutation in ABCB11, encoding BSEP, underlay progressive familial intrahepatic cholestasis (PFIC) - or 'neonatal hepatitis,' suggesting PFIC - that was associated with HCC in young children," scientists in England reported.
"We studied 11 cases of pediatric HCC in the setting of PFIC or 'neonatal hepatitis' suggesting PFIC,"...
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Source: Cancer Weekly (2006-10-10)
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