Acute Myeloid Leukemia
Acute myeloid leukemia-associated MLL partial tandem duplications persist lifelong
Published in Cancer Weekly, October 17th, 2006
"AML-associated MLL-PTD contribute to leukemogenesis by a gain of function and confer an unfavorable prognosis. Like other leukemia associated aberrations they are also present in healthy adults. To delineate the leukemogenic mechanism we tracked down MLL-PTD in normal hematopoiesis and investigated cord blood samples," scientists in Germany report.
According to J. Basecke and colleagues at the University of Gottingen "MLL-PTD were observed in 56/60 (93%) of all cord bloods. In contrast to AML, the transcript frequency in cord blood was four log scales lower as...
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Source: Cancer Weekly (2006-10-17)
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