Gene Research
Fli1 and Ets1 marshal the connective tissue growth factor gene in fibrotic diseases
Published in Cancer Weekly, October 24th, 2006
"CCN2, an important regulator of angiogenesis, chondrogenesis, and wound healing, is over-expressed in a majority of fibrotic diseases and in various tumors. This study investigated regulation of CCN2 gene expression by Ets family of transcription factors, focusing on two members, Fli1 and Ets1, with deregulated expression during fibrosis and tumorigenesis," scientists writing in the Journal of Biological Chemistry report.
"We show that Ets1 and Fli1 have opposite effects on CCN2 gene expression. Ets1 functions as an activator of CCN2 transcription,...
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Source: Cancer Weekly (2006-10-24)
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