Prostate Cancer
Prostate cancer angiogenesis is subject to CEA-related cell adhesion molecule-1 control
Published in Cancer Weekly, October 24th, 2006
According to recent research published in the journal Oncogene, "We demonstrate here that epithelial CEACAM1 downregulation in prostate intraepithelial neoplasia (PIN) is inversely correlated with its upregulation in adjacent blood vessels.
"CEACAM1 silencing in prostate cancer cell line DU-145 via small interfering ribonucleic acid (siRNA) increased but its overexpression suppressed the expression of angiogenic/lymphangiogenic factors such as vascular endothelial growth factor (VEGF)-A, -C and -D, and angiogenic inhibitor collagen...
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Source: Cancer Weekly (2006-10-24)
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