Squamous Cell Carcinoma
Oral and pharyngeal squamous cell cancer not prognosticated by cyclooxygenase-2 expression
Published in Cancer Weekly, October 24th, 2006
"COX-2 expression is upregulated in transformed cells and in malignant tissues, including tumours of the head and neck, and it has prognostic significance in many types of cancer. COX-2 expression is suppressed by the wild-type but not by the mutant tumor suppressor gene TP53," scientists writing in the journal Oncology Reports reported.
"The purpose of this study was to investigate the association between the expression of COX-2 and the clinical outcome in patients with oral and pharyngeal SCC, and to examine its relationship to p53,"...
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Source: Cancer Weekly (2006-10-24)
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