Radiotherapy

Histone acetyltransferase inhibitors may increase sensitivity of tumors to radiation therapy

Published in Cancer Weekly, October 24th, 2006

Histone acetyltransferases (HATs) regulate DNA damage response, thus HAT inhibitors may increase sensitivity of tumors to radiation therapy.

According to a study from the United States, "HATs regulate transcription, chromatin structure and DNA repair. Here, we utilized a novel HAT inhibitor, anacardic acid, to examine the role of HATs in the DNA damage response."

"Anacardic acid inhibits the Tip60 HAT in vitro, and blocks the Tip60-dependent activation of the ATM and DNA-PKcs protein kinases by DNA damage in vivo. Further, anacardic acid sensitizes human tumor cells to the cytotoxic effects of ionizing radiation," explained Y.L. Sun and colleagues,...

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Source: Cancer Weekly (2006-10-24)

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