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Esophageal Cancer

Esophageal adenocarcinoma risk linked to XPD 751Gln allele

Published in Cancer Weekly, October 31st, 2006

An increased risk of esophageal adenocarcinoma was linked to the XPD 751Gln allele.

According to recent research from Sweden, "Mechanisms behind the strong associations of esophageal adenocarcinoma risk with gastroesophageal reflux (GOR) and body mass remain to be defined. In a nationwide population-based case-control study, we examined associations of polymorphisms in the DNA repair genes XPD, XPC, XRCC1 and XRCC3 with risk of esophageal adenocarcinoma, squamous-cell carcinoma (SCC) and gastric cardia adenocarcinoma, and paid special attention to possible interactions with symptomatic reflux or body mass."

"We collected blood samples from 96, 81 and...

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