Research from Tokyo Women's Medical University, Department of Radiology yields new findings on monoclonal antibodies

New investigation results, "Enhancement of radiosensitivity by dual inhibition of the HER family with ZD1839 ("Iressa") and trastuzumab ("Herceptin")," are detailed in a study published in International Journal of Radiation, Oncology, Biology, Physics. "The aims of this study were twofold: (1) to examine the effects of dual inhibition of 2 members of the HER family, the epidermoid growth factor receptor (EGFR) and HER2/neu, by gefitinib (ZD1839) and trastuzumab on radiosensitivity; and (2) to explore the molecular mechanism of radiosensitization especially focusing on the survival signal transduction pathways by using A431 human vulvar squamous carcinoma cells expressing EGFR and HER2/neu....

Want to see the full article?

• Purchase this article for only $3.00