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Apoptosis

Ewing sarcoma cell apoptosis induced by arsenic trioxide

Published in Cancer Weekly, November 14th, 2006

Ewing sarcoma (ES) cell apoptosis could be induced by arsenic trioxide (As2 O3 ) and should be studied as a candidate for future protocols.

According to recent research from France, "ES, a highly malignant pediatric tumor, is consistently associated with translocations that fuse the EWS gene with a member of the ETS family gene, most commonly FLI-1. Despite significant advances with multiagent chemotherapy, surgery and radiotherapy, about 40% of ES patients still die from the disease."

"It is therefore necessary to explore novel agents for possible treatment of this tumor," relayed J. Mathieu and colleagues, INSERM. "Here the...

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