Cancer Therapy

Research identifies a human enzyme that could be programmed to kill cancer cells

Published in Cancer Weekly, December 12th, 2006

A new study conducted by scientists at Children's Hospital Oakland Research Institute (CHORI) identifies a specific enzyme that can cause the death of cancer cells. Researchers studied the behavior of an enzyme called sphingosine phosphate lyase (SPL), which can regulate cell growth and death by lowering the levels of a natural, growth-promoting lipid called sphingosine-1-phosphate, or S1P.

The study, led by Julie Saba, MD, PhD is the first to link the SPL enzyme to cancer, and it appears in a recent issue of the Proceedings of the National Academy of Sciences. Researchers identified SPL as a key regulator of cancer cells. They discovered that if the cancer cells...

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Source: Cancer Weekly (2006-12-12)

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