Cancer Therapy

Diarrhea as side effect of chemotherapy may be caused by predisposition

Published in Cancer Weekly, December 26th, 2006

A troublesome side effect caused by some cancer drugs appears to be caused by a broken "pump" in the liver that fails to push these medicines into a "drain," according to investigators at St. Jude Children's Research Hospital. The finding offers clinicians a way to identify patients who are likely to develop diarrhea as a side effect from taking these drugs, the researchers said.

The discovery also has implications for people taking other drugs, since this pump controls the blood levels of many of the prescription drugs on the market. This study is the first to show that a specific gene mutation disables the pump-a protein called ABCG2-preventing it from disposing of...

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Source: Cancer Weekly (2006-12-26)

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