Acute Myeloid Leukemia Therapy
Scientists at University of California, Moores Cancer Center describe research in acute myeloid leukemia therapy
Published in Cancer Weekly, January 2nd, 2007
New investigation results, "Cytotoxic activity of gemtuzumab ozogamicin (Mylotarg) in acute myeloid leukemia correlates with the expression of protein kinase Syk," are detailed in a study published in Leukemia. "Acute myeloid leukemia (AML) cells express the cell surface antigen CD33 that, upon ligation with a monoclonal antibody (mAb), is a downregulator of cell growth in a Syk-dependent manner. An anti-CD33 mAb coupled to a toxin, gemtuzumab ozogamicin (GO), is used for the treatment of AML (Mylotarg)," scientists in the United States report.
"Therefore, we investigated whether the response of AML cells to GO treatment also depends on Syk expression. Forty primary AML...
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Source: Cancer Weekly (2007-01-02)
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