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Cancer Gene Therapy

Researchers at Seoul National University have published new data on cancer gene therapy

Published in Cancer Weekly, January 16th, 2007

New research, "A biodegradable poly(ester amine) based on polycaprolactone and polyethylenimine as a gene carrier," is the subject of a report. "The aim of research was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biodegradable polymers, in particular, poly(ester amine). (PEAs), suitable for non-viral gene therapy. Poly(ester amine). were successfully synthesized by Michael addition reaction between polycaprolactone (PCL) diacrylate and low molecular weight polyethylenimine (PEI). PEA/DNA complexes showed effective and stable DNA condensation with the particle sizes below 200nm, implicating its potential for intracellular delivery," researchers in Seoul, South...

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