Cancer Therapy

Profiling of cancer genes may lead to better and earlier detection

Published in Cancer Weekly, January 16th, 2007

A research team at University of Texas Southwestern Medical Center has for the first time identified several genes whose expression is lost in four of the most common solid human cancers - lung, breast, prostate and colon cancer. The findings, which researchers say could form the basis for a new early detection screen for certain cancers, are published in the online journal Public Library of Science Medicine.

The expression of genes that inhibit cancer development, so-called tumor suppressor genes, is often lost in tumor cells. This can occur through a mutation in the gene's DNA sequence or through deletion of the gene. Loss of tumor suppression function also can...

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Source: Cancer Weekly (2007-01-16)

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