Lung Cancer Therapy
Study results from Vanderbilt University, Vanderbilt-Ingram Comprehensive Cancer Center provide new insights into lung cancer therapy
Published in Cancer Weekly, January 23rd, 2007
Fresh data on lung cancer are presented in the report "Epidermal growth factor receptor (EGFR) antibody down-regulates mutant receptors and inhibits tumors expressing EGFR mutations. Activating mutations in the kinase domain of the EGF receptor have been reported in non-small cell lung cancer. The majority of tumors expressing these mutants are sensitive to ATP mimetics that inhibit the EGFR tyrosine kinase," scientists in the United States report.
"The effect of antibodies that bind to the ectodomain of the receptor is less clear. We report herein the effects and mechanisms of action of the antibody cetuximab in lung cancer cells that naturally express receptor...
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Source: Cancer Weekly (2007-01-23)
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