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Breast Cancer

Tumor cells replace the need for growth factors by using other stimulators

Published in Cancer Weekly, January 23rd, 2007

A study using a human breast cancer cell line, which appears in the Journal of Clinical Investigation, shows that increased amounts of a molecule that can activate the EGF receptor (TGF-alpha) can also cause the tumor cells to become independent of EGF.

One feature of tumor cells that makes them cancerous is their ability to grow in the absence of the signals that normal cells require to grow. For example, breast cancer is often associated with the ability of the tumor cells to grow in the absence of a growth factor known as EGF.

In many cases, the tumor cells become independent of EGF through genetic mutations that result in the receptor for EGF or...

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