Cancer Gene Therapy

Kanazawa University describes research in cancer gene therapy

Published in Cancer Weekly, January 30th, 2007

Fresh data on cancer are presented in the report "MicroRNA regulates the expression of human cytochrome P450 1B1." According to recent research from Kanazawa, Japan, "MicroRNAs (miRNA) are small noncoding RNAs that regulate gene expression through translational repression or mRNA cleavage. Here, we found that cytochrome P450 (CYP), a superfamily of drug-metabolizing enzymes, is a target of miRNA."

"Human CYP1B1, which is highly expressed in estrogen target tissues, catalyzes the metabolic activation of various procarcinogens and the 4-hydroxylation of 17beta-estradiol. CYP1B1 protein is abundant in cancerous tissues. We identified a near-perfect matching sequence with...

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Source: Cancer Weekly (2007-01-30)

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