Cancer Gene Therapy
Data on cancer gene therapy reported by researchers at University Hospital
Published in Cancer Weekly, February 6th, 2007
Research findings, "TRAIL promotes metastasis of human pancreatic ductal adenocarcinoma," are discussed in a new report. "Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has attracted considerable attention for its potential use in tumor therapy, as some recombinant variants of this ligand induce apoptosis in tumor cells without harming most normal cells. Here, we show that TRAIL strongly induces the expression of the proinflammatory cytokines interleukin-8 and monocyte chemoattractant protein 1 and enhances the invasion of apoptosis-resistant pancreatic ductal adenocarcinoma cells in vitro by upregulation of the urokinase-type plasminogen activator expression,"...
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Source: Cancer Weekly (2007-02-06)
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