Cancer Weekly
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Genetics & Genomics
UCLA researchers discover genes linked to lymphoma that may open way for new targeted drugs
February 27th, 2007
Researchers at The University of California Los Angeles (UCLA) have identified genes that when inactivated help cause B-cell non-Hodgkin lymphoma (NHL). These genetic defects may also be involved in promoting the formation of other cancers since they can inactivate normal tumor-suppressing gene activities in a range of cell types. The team led by Michael Teitell, MD, PhD, and funded by The Leukemia & Lymphoma Society, used genetically engineered mice to accurately mimic human B-cell cancers. They had previously published research in which they identified frequent genetic abnormalities in cancer cells from NHL patients, namely defects in the TCL1 gene, and showed that...
Source: Cancer Weekly (2007-02-27)
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