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Cancer Gene Therapy
Data on cancer gene therapy reported by researchers at Beatson Laboratories
February 27th, 2007
Fresh data on cancer gene therapy are presented in the report "Modulation of telomerase promoter tumor selectivity in the context of oncolytic adenoviruses. The telomerase RNA (hTR) and reverse transcriptase (hTERT) promoters are active in most cancer cells, but not in normal cells, and are useful for transcriptional targeting in gene therapy models. Telomerase-specific conditionally replicating adenoviruses (CRAd) are attractive vectors because they should selectively lyse tumor cells," researchers in Bearsden, the United Kingdom report. "Here, we compare CRAds, in which either the hTR or hTERT promoter controls expression of the adenovirus E1A gene. In...
Source: Cancer Weekly (2007-02-27)
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