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Cancer Gene Therapy
Findings from Tokyo Medical and Dental University broaden understanding of cancer gene therapy
February 27th, 2007
Research findings, "Knockdown of XAB2 enhances all-trans retinoic acid-induced cellular differentiation in all-trans retinoic acid-sensitive and -resistant cancer cells," are discussed in a new report. "Xeroderma pigmentosum group A (XPA)-binding protein 2 (XAB2) is composed of 855 amino acids, contains 15 tetratricopeptide repeat motifs, and associates with Cockayne syndrome group A and B proteins and RNA polymerase II, as well as XPA. In vitro and in vivo studies showed that XAB2 is involved in pre-mRNA splicing, transcription, and transcription-coupled DNA repair, leading to preimplantation lethality, and is essential for mouse embryogenesis," scientists writing in the journal Cancer...
Source: Cancer Weekly (2007-02-27)
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