Gene Therapy
New gene therapy study results from Wenzhou Medical College, Medical College described
Published in Cancer Weekly, March 6th, 2007
New investigation results, "High level expression of human endostatin in Pichia pastoris using a synthetic gene construct," are detailed in a study published in Applied Microbiology and Biotechnology. "Endostatin, a 20-kDa C-terminal fragment derived from type XVIII collagen, is a potent angiogenesis inhibitor and an antitumor factor. To improve the production of recombinant human endostatin on increasing demand in clinical practice, we constructed an artificial gene encoding its mature peptide sequence in human collagen XVIII," researchers in Wenzhou, People's Republic of China report.
"The synthetic gene consisted of 20 codons in preference in methylotropic...
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Source: Cancer Weekly (2007-03-06)
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