Cancer Gene Therapy
Research from University of California, Department of Medicine provides new data on cancer gene therapy
Published in Cancer Weekly, March 20th, 2007
A report, "Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin," is newly published data in Gastroenterology. "Colon cancers with high-frequency microsatellite instability (MSI-H) develop frameshift mutations in tumor suppressors as part of their pathogenesis. ACVR2 is mutated at its exon 10 polyadenine tract in >80% of MSI-H colon cancers, coinciding with loss of protein," scientists in the United States report.
"ACVR2 transmits the growth effects of activin via phosphorylation of SMAD proteins to affect gene transcription. The functional effect of activin in colon cancers has not been studied. We...
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Source: Cancer Weekly (2007-03-20)
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