Breast Cancer Genetics
Investigators at Okayama University have published new data on breast cancer genetics
Published in Cancer Weekly, May 8th, 2007
Data detailed in "Different transcriptional strategies for ccn2/ctgf gene induction between human chondrocytic and breast cancer cell lines" have been presented. "Connective tissue growth factor (CTGF/CCN2) plays a critical role in endochondral bone formation; however, CCN2 also promotes angiogenesis and bone metastasis in breast cancer. Chondrocytic HCS-2/8 cells and breast cancer MDA231 cells produce over 6 times more CCN2 than any other cell type," scientists writing in the journal Biochimie report.
"In this study, we demonstrate that these cell lines employ different transcriptional strategies for ccn2 gene induction. Four tandem copies of the dominant...
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Source: Cancer Weekly (2007-05-08)
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