Colon Cancer Genetics
Memorial Sloan Kettering Cancer Center, Department of Surgery details research in colon cancer genetics
Published in Cancer Weekly, May 8th, 2007
Research findings, "Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management," are discussed in a new report. "This study summarizes our initial experience with prospective, single-amplicon (mutation-specific) A636P testing in Ashkenazi Jewish patients at risk for Hereditary Nonpolyposis Colorectal Cancer (HNPCC).: We previously described a founder mutation, MSH2*1906G >C (A636P) that causes HNPCC in 8/1345 (0.59%) of Ashkenazim with colorectal cancer. The mutation was more common in Ashkenazim diagnosed at <or=40 years (7%)," scientists in the United States report.
"Twenty-seven Ashkenazi...
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Source: Cancer Weekly (2007-05-08)
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