Colon Cancer Genetics
Researchers from University of Birmingham, Institute of Biomedical Research provide details of new studies and findings in the area of colon cancer genetics
Published in Cancer Weekly, May 8th, 2007
A new study, "Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity," is now available. "Genetic instability (GI) is a hallmark feature of tumor development. Securin, also known as pituitary tumor transforming gene (PTTG), is a mitotic checkpoint protein which is highly expressed in numerous cancers, is associated with tumor invasiveness, and induces GI in thyroid cells," investigators in the United Kingdom report.
"We used fluorescence inter-simple sequence repeat PCR to assess GI caused primarily by DNA breakage events in 19 colorectal tumors. GI values ranged significantly, with Dukes' stage C&D colorectal tumors...
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Source: Cancer Weekly (2007-05-08)
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