Gene Therapy
New gene therapy study findings reported from Harvard University, Dana-Farber Cancer Institute
Published in Cancer Weekly, May 8th, 2007
New investigation results, "A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma," are detailed in a study published in Oncogene. According to recent research from the United States, "Bcl-2 or Bcl-X(L) confers resistance to chemotherapy in multiple myeloma (MM). Here we characterized the effects of ABT-737, a potent small-molecule inhibitor of antiapoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w with markedly higher affinity than previously reported compounds, on human MM cells."
"ABT-737 induces apoptosis in MM cells, including those resistant to conventional therapy. Examination of purified patient MM cells demonstrated similar results,...
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Source: Cancer Weekly (2007-05-08)
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