Life Sciences
Research from University of Colorado, Denver and Health Sciences Center in the area of life sciences published
Published in Cancer Weekly, May 8th, 2007
A new study, "RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene," is now available. According to recent research from the United States, "TRC8/RNF139 and von Hippel-Lindau (VHL) both encode E3 ubiquitin (Ub) ligases mutated in clear-cell renal carcinomas (ccRCC). VHL, inactivated in nearly 70% of ccRCCs, is a tumor suppressor encoding the targeting subunit for a Ub ligase complex that downregulates hypoxia-inducible factor-alpha."
"TRC8/RNF139 is a putative tumor suppressor containing a sterol-sensing domain and a RING-H2 motif essential for Ub ligase activity. Here we report that human kidney cells are growth inhibited...
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Source: Cancer Weekly (2007-05-08)
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