Pancreatic Cancer Genetics

Study results from University Hospital, Department of Internal Medicine I update understanding of pancreatic cancer genetics

Published in Cancer Weekly, May 8th, 2007

Data detailed in "Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer" have been presented. According to recent research from Ulm, Germany, "Pancreatic cancer is a devastating disease with poor prognosis. Production of large quantities of extracellular matrix and early metastasis are characteristics of this disease."

"One important step in the development of various cancers is the loss of E-cadherin gene expression or inactivation of E-cadherin mediated cell-cell adhesion. It has been shown that collagen type I promotes downregulation of E-cadherin expression, which correlates with enhanced cell migration and...

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Source: Cancer Weekly (2007-05-08)

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