Drug Resistance
Research from National Health Research Institutes provide new insights into drug resistance
Published in Cancer Weekly, May 15th, 2007
Researchers detail in "Sulfasalazine suppresses drug resistance and invasiveness of lung adenocarcinoma cells expressing AXL," new data in drug resistance. According to a study from Taipei, Taiwan, "Metastasis and drug resistance are the major causes of mortality in patients with non-small cell lung cancer (NSCLC). Several receptor tyrosine kinases (RTKs), including AXL, are involved in the progression of NSCLC."
"The AXL/MER/SKY subfamily is involved in cell adhesion, motility, angiogenesis, and signal transduction and may play a significant role in the invasiveness of cancer cells. Notably, no specific inhibitors of AXL have been described. A series of CL1 sublines...
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Source: Cancer Weekly (2007-05-15)
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